Semiconducting Polymer Nanoreporters for Near‐Infrared Chemiluminescence Imaging of Immunoactivation

Real‐time in vivo imaging of immunoactivation is critical for longitudinal evaluation of cancer immunotherapy, which, however, is rarely demonstrated. This study reports semiconducting polymer nanoreporters (SPNRs) with superoxide anion (O 2 •− )‐activatable chemiluminescence signals for in vivo imaging of immunoactivation during cancer immunotherapy. SPNRs are designed to comprise an SP and a caged chemiluminescence phenoxy‐dioxetane substrate,...