Cell biology

Biology

Extracellular

Receptor

Agonist

Biochemistry

Compartmentalization (fire protection)

Immunology

Adenosine

Immune system

Enzyme

Adenosine receptor

Cancer Cell

Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede the development of effective adenosine-based therapeutics include: (1) lack of consideration of redundant pathways controlling ATP and adenosine levels; (2) lack of distinction between receptor-dependent and -independent effects of adenosine, and (3) focus on extracellular adenosine without consideration of intracellular metabolism and compartmentalization. In light of current clinical trials, we provide an overview of adenosine metabolism and point out the need for a more careful evaluation of the entire purinome in emerging cancer therapies.

Adenosine Metabolism: Emerging Concepts for Cancer Therapy