Biotechnology

Biology

Reactive oxygen species

Endocrinology

Biochemistry

Rheumatoid arthritis

Immunology

In vivo

Superoxide dismutase

Arthritis

Oxidative stress

Antioxidant

Internal medicine

Pathological

Pharmacology

Medicine

Therapeutic effect

Chemistry

Pathology

Diabetes mellitus

PubMed

Superoxide dismutases (SODs) constitute a very important antioxidant defense against oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive oxygen species-mediated diseases. The present review describes the therapeutic effects of SOD in various physiological and pathological conditions such as cancer, inflammatory diseases, cystic fibrosis, ischemia, aging, rheumatoid arthritis, neurodegenerative diseases, and diabetes. However, the enzyme has certain limitations in clinical applications. Therefore, SOD conjugates and mimetics have been developed to increase its therapeutic efficiency. Here, an overview is provided of some in vivo therapeutic effects observed with SOD.

Therapeutic potentials of superoxide dismutase.