Catalysis

Process (computing)

Engineering

Materials science

Scope (computer science)

Operating system

Computer science

Reductive amination

Business

Process development

Biochemical engineering

Combinatorial chemistry

Nanotechnology

Organic chemistry

Process management

Amination

Chemistry

Programming language

Chemical Reviews

Transition metal-mediated formation of C-N bonds is an essential synthetic methodology. The discovery of the Chan-Lam amination provided a C-N bond forming process that was mild, convenient, and inexpensive, offering an alternative to complementary methods using other transition metals (TMs). Over the past 20 years, this reaction has seen considerable development in its scope of application, uptake into industry, and understanding of its mechanism. This review provides an account of the development of the Chan-Lam amination, highlighting progress and notable examples of application since 2011. Focus is given to evolution in mechanistic understanding and selected applications of the methodology within medicinal and process chemistry.

Mechanistic Development and Recent Applications of the Chan–Lam Amination