Engineered nanomedicines with enhanced tumor penetration

Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is inefficient tumor penetration caused by specific tumor microenvironments, such as insufficient blood supply, high-density tumor cells and extracellular matrix, and increased interstitial fluid pressure. To date, several strategies, including the modulation of tumor...