Reductive Amination in the Synthesis of Pharmaceuticals
Abstract
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. It is one of the key approaches to C–N bond construction due to its operational easiness and a wide toolbox of protocols. Recent studies show that at least a quarter of C–N bond-forming reactions in the pharmaceutical industry are performed via reductive...
Paper Details
Title
Reductive Amination in the Synthesis of Pharmaceuticals
Published Date
Oct 21, 2019
Journal
Volume
119
Issue
23
Pages
11857 - 11911
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Notes
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