Determination of iodine detectability in different types of multiple-energy images for a photon-counting detector computed tomography system.

Published on Oct 1, 2019in Journal of medical imaging
· DOI :10.1117/1.JMI.6.4.043501
Wei Zhou13
Estimated H-index: 13
(Mayo Clinic),
Gregory Michalak12
Estimated H-index: 12
(Mayo Clinic)
+ 5 AuthorsShuai Leng53
Estimated H-index: 53
(Mayo Clinic)
In addition to low-energy-threshold images (TLIs), photon-counting detector (PCD) computed tomography (CT) can generate virtual monoenergetic images (VMIs) and iodine maps. Our study sought to determine the image type that maximizes iodine detectability. Adult abdominal phantoms with iodine inserts of various concentrations and lesion sizes were scanned on a PCD-CT system. TLIs, VMIs at 50 keV, and iodine maps were generated, and iodine contrast-to-noise ratio (CNR) was measured. A channelized Hotelling observer was used to determine the area under the receiver-operating-characteristic curve (AUC) for iodine detectability. Iodine map CNR (0.57  ±  0.42) was significantly higher ( P P P
📖 Papers frequently viewed together
9 Authors (Wei Zhou, ..., Shuai Leng)
1 Citations
4 Citations
#1Bhavik N. Patel (Stanford University)H-Index: 20
#2Federica Vernuccio (Duke University)H-Index: 14
Last. Daniele Marin (Duke University)H-Index: 39
view all 11 authors...
OBJECTIVE. The purpose of this study was to determine whether a single, uniform normalized iodine threshold reduces variability and enables reliable differentiation between vascular and nonvascular...
12 CitationsSource
#1Shuai LengH-Index: 53
#2Kishore Rajendran (Mayo Clinic)H-Index: 11
Last. Cynthia H. McColloughH-Index: 76
view all 10 authors...
OBJECTIVE: The aims of this study were to quantitatively assess two new scan modes on a photon-counting detector computed tomography system, each designed to maximize spatial resolution, and to qualitatively demonstrate potential clinical impact using patient data. MATERIALS AND METHODS: This Health Insurance Portability Act-compliant study was approved by our institutional review board. Two high-spatial-resolution scan modes (Sharp and UHR) were evaluated using phantoms to quantify spatial reso...
33 CitationsSource
#1Joel G. Fletcher (Mayo Clinic)H-Index: 84
#2Jeff L. Fidler (Mayo Clinic)H-Index: 36
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 11 authors...
This experience with a single CT platform, and the range of lower doses with performance noninferior to routine dose levels, shows that substantial dose reduction in contrast-enhanced abdominal CT may be possible whether or not iterative reconstruction is used.
12 CitationsSource
#1Roy P. Marcus (Mayo Clinic)H-Index: 2
#1Roy P. Marcus (Mayo Clinic)H-Index: 14
Last. Cynthia H. McColloughH-Index: 76
view all 10 authors...
The evaluated photon-counting–detector CT system has the potential to improve the automatic characterization of small stones (≤3 mm).
17 CitationsSource
#1Bhavik N. Patel (Stanford University)H-Index: 20
#2Michael D. Rosenberg (Duke University)H-Index: 5
Last. Daniele Marin (Duke University)H-Index: 39
view all 7 authors...
OBJECTIVE. The objective of this study is to determine whether single-phase contrast-enhanced dual-energy CT (DECT) material attenuation analysis improves the characterization of small (< 2.0 cm) incidental indeterminate hypoattenuating hepatic lesions, compared with conventional single-energy CT evaluation. MATERIALS AND METHODS. This retrospective study involved 55 patients (24 men and 31 women; mean [± SD] age, 63.9 ± 15.3 years) with 77 incidental hypoattenuating hepatic lesions (59 benign a...
9 CitationsSource
#1G. Jay Hanson (Mayo Clinic)H-Index: 1
#2Gregory Michalak (Mayo Clinic)H-Index: 12
Last. Joel G. Fletcher (Mayo Clinic)H-Index: 84
view all 15 authors...
Purpose Single-energy low tube potential (SE-LTP) and dual-energy virtual monoenergetic (DE-VM) CT images both increase the conspicuity of hepatic lesions by increasing iodine signal. Our purpose was to compare the conspicuity of proven liver lesions, artifacts, and radiologist preferences in dose-matched SE-LTP and DE-VM images.
11 CitationsSource
#1Megan C. Jacobsen (University of Texas Health Science Center at Houston)H-Index: 7
#2Xinhui DuanH-Index: 18
Last. Rick R. Layman (University of Texas MD Anderson Cancer Center)H-Index: 9
view all 6 authors...
Multiple studies in the literature have proposed diagnostic thresholds based on Multi-Energy Computed Tomography (MECT) iodine maps. However, it is critical to determine the minimum detectable iodine concentration for MECT systems to assure the clinical accuracy for various measured concentrations for these image types. In this study, seven serial dilutions of iohexol were made with concentrations from 0.03 to 2.0 mg Iodine/mL in 50 mL centrifuge tubes. The dilutions and one blank vial were scan...
2 CitationsSource
#1Wei Zhou (Mayo Clinic)H-Index: 13
#2Rachel Schornak (Mayo Clinic)H-Index: 1
Last. Shuai Leng (Mayo Clinic)H-Index: 53
view all 9 authors...
Photon counting detector (PCD) based multi-energy CT is able to generate different types of images such as virtual monoenergetic images (VMIs) and material specific images (e.g., iodine maps) in addition to the conventional single energy images. The purpose of this study is to determine the image type that has optimal iodine detection and to determine the lowest detectable iodine concentration using a PCD-CT system. A 35 cm body phantom with iodine inserts of 4 concentrations and 2 sizes was sca...
1 CitationsSource
#1Orhan Ozguner (Case Western Reserve University)H-Index: 5
#2Amar Dhanantwari (Philips)H-Index: 9
Last. David W. Jordan (Case Western Reserve University)H-Index: 15
view all 6 authors...
This work evaluated the performance of a detector-based spectral CT system by obtaining objective reference data, evaluating attenuation response of iodine and accuracy of iodine quantification, and comparing conventional CT and virtual monoenergetic images in three common phantoms. Scanning was performed using the hospital's clinical adult body protocol. Modulation transfer function (MTF) was calculated for a tungsten wire and visual line pair targets were evaluated. Image noise power spectrum ...
20 CitationsSource
#1Wei Zhou (Mayo Clinic)H-Index: 13
#2J. Montoya (Mayo Clinic)H-Index: 4
Last. Shuai Leng (Mayo Clinic)H-Index: 53
view all 8 authors...
An ultra-high resolution (UHR) mode, with a detector pixel size of 0.25 mm×0.25 mm relative to isocenter, has been implemented on a whole body research photon-counting detector (PCD) computed tomography (CT) system. Twenty synthetic lung nodules were scanned using UHR and conventional resolution (macro) modes and reconstructed with medium and very sharp kernels. Linear regression was used to compare measured nodule volumes from CT images to reference volumes. The full-width-at-half-maximum of th...
7 CitationsSource
Cited By2
#1Jiří FerdaH-Index: 14
#2Tomas VendisH-Index: 1
Last. Hynek MírkaH-Index: 9
view all 10 authors...
Abstract Objectives to assess the feasibility of CT with an integrated photon-counting-detector system (PC-CT) in the body imaging of clinical patients. Methods 120 examinations using photon counting detector CT were evaluated in six groups: 1/ a standard-dose lung, 2/ low-dose lung, 3/ ultra-high resolution (UHR) lung, 4/ standard-dose abdominal, 5/ lower-dose abdominal, 6/ UHR abdominal CTA. All CT examinations were performed on a single-source prototype device equipped with a photon counting ...
#1Mats Danielsson (KTH: Royal Institute of Technology)H-Index: 32
#2Mats Persson (KTH: Royal Institute of Technology)H-Index: 11
Last. Martin SjölinH-Index: 4
view all 3 authors...
The introduction of photon-counting detectors is expected to be the next major breakthrough in clinical x-ray computed tomography (CT). During the last decade, there has been considerable research activity in the field of photon-counting CT, in terms of both hardware development and theoretical understanding of the factors affecting image quality. In this article, we review the recent progress in this field with the intent of highlighting the relationship between detector design considerations a...
1 CitationsSource