Ligand (biochemistry)

Metathesis

Receptor

Organic chemistry

Polymer chemistry

Combinatorial chemistry

Phosphine

Olefin metathesis

Olefin fiber

Catalysis

Chemistry

Carbene

Pyridine

Polymerization

Organometallic chemistry

Polymer

Organic synthesis

Biochemistry

Ruthenium

ChemCatChem

Mechanochemical synthesis of nine contemporary ruthenium catalysts used for olefin metathesis is described, being the first reported example of formation of Ru carbene organometallic complexes in solid state. Three key organometallic transformations commonly used in the synthesis of the second and third generations of Ru catalysts in solution—phosphine ligand (PCy 3 ) exchange with in situ formed N‐heterocyclic carbene (NHC) ligand, PCy 3 to pyridine ligand replacement, and benzylidene ligands interchange—were proved to work under mechanochemical conditions, affording the targets in high purity. Mechanochemical approach not only requires less amounts of organic solvent (null for synthesis, only for purification) and is scalable, but also allows for transformations that were reported impossible in the solution phase.

A Gentler Touch: Synthesis of Modern Ruthenium Olefin Metathesis Catalysts Sustained by Mechanical Force