Internal medicine

Cohort study

Nonalcoholic fatty liver disease

Disease

Population

World Wide Web

Index (typography)

Cholesterol

Body mass index

Fatty liver

Triglyceride

Computer science

Cohort

Medicine

Environmental health

Canadian Journal of Gastroenterology and Hepatology

Background . The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD. Here we investigated whether the TyG-index can be used to predict incident NAFLD. Methods . This historical cohort study included 16,093 apparently healthy Japanese individuals. The TyG-index was calculated by the established formula: TyG = Ln [TG (mg/dl) × FPG (mg/dl)/2]. Fatty liver was diagnosed based on the subjects’ abdominal ultrasonography results. We divided the subjects into tertiles according to the levels of TyG-index. Hazard ratios (HRs) of the TyG-index for incident NAFLD were calculated by a Cox proportional hazards regression model. Results . During the observation period, 27.4% of the men and 11.0% of the women developed NAFLD. The highest TyG-index tertile (men, 8.48 ≤ TyG and women, 7.97 ≤ TyG) (adjusted HR 1.67, 95% CI 1.44–1.94, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> in the men and 2.06, 1.59–2.70, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> in the women) and the middle TyG-index tertile (men, 8.00 &lt; TyG ≤ 8.48 and women, 7.53 &lt;TyG ≤7.97) (1.33, 1.15–1.54, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> in the men and 1.52, 1.16–2.01, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mrow><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math> in the women) presented a significantly higher risk of incident NAFLD compared to the lowest TyG-index tertile (men, TyG &lt; 8.00 and women, TyG &lt; 7.53). Conclusions . Our findings demonstrate that the TyG-index is significantly associated with incident NAFLD.

The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study