European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020.

Published on Jan 1, 2020in Journal of Pediatric Gastroenterology and Nutrition2.839
路 DOI :10.1097/MPG.0000000000002497
Steffen Husby58
Estimated H-index: 58
(OUH: Odense University Hospital),
Sibylle Koletzko6
Estimated H-index: 6
(University of Warmia and Mazury in Olsztyn)
+ 18 AuthorsKatharina Julia Werkstetter5
Estimated H-index: 5
(Boston Children's Hospital)
Sources
Abstract
ABSTRACTObjectives:The ESPGHAN 2012 coeliac disease (CD) diagnostic guidelines aimed to guide physicians in accurately diagnosing CD and permit omission of duodenal biopsies in selected cases. Here, an updated and expanded evidence-based guideline is presented.Methods:Literature databases and other
馃摉 Papers frequently viewed together
References94
Newest
#1Michelle A. E. Jansen (EUR: Erasmus University Rotterdam)H-Index: 11
#2Menno C. van Zelm (EUR: Erasmus University Rotterdam)H-Index: 36
Last. Johanna C. Escher (EUR: Erasmus University Rotterdam)H-Index: 53
view all 9 authors...
Background The objective of our study was to assess whether TG2A levels in the healthy childhood population can be predictive of subclinical CD.
Source
#1Daniel C. Adelman (UCSF: University of California, San Francisco)H-Index: 29
#2Joseph A. Murray (Mayo Clinic)H-Index: 102
Last. Ciaran P. Kelly (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 91
view all 6 authors...
Small intestinal histologic abnormalities in celiac disease include atrophy of the intestinal villi, hypertrophy of the crypts and lymphocytic infiltration of intraepithelial spaces and lamina propria. These findings are central to diagnosis and their severity and change over time are valuable to mo
Source
#1Vincenzo VillanacciH-Index: 60
#2Luisa Lorenzi (University of Brescia)H-Index: 12
Last. M. Luisa Mearin (LUMC: Leiden University Medical Center)H-Index: 21
view all 15 authors...
Aim of the current study was to evaluate the inter-observer agreement between pathologists in the diagnosis of celiac disease (CD), in the qualified context of a multicenter study. Biopsies from the PreventCD study, a multinational- prospective- randomized study in children with at least one-first-degree relative with CD and positive for HLA-DQ2/HLA-DQ8. Ninety-eight biopsies were evaluated. Considering diagnostic samples with villous atrophy (VA), the agreement was satisfactory ( = 0.84), but m...
Source
#1Katharina Julia Werkstetter (Boston Children's Hospital)H-Index: 5
#2Ilma Rita Korponay-Szab贸 (University of Debrecen)H-Index: 43
view all 99 authors...
Background & Aims The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach. Methods We colle...
Source
: In this prospective study, we evaluated the effect of gluten-free diet (GFD) in a cohort of 65 children with potential celiac disease. Patients received GFD for signs/symptoms (N鈥=鈥47) or parents' choice (N鈥=鈥18). Most frequent signs/symptoms were low body mass index (36%), recurrent abdominal pain (34%), and diarrhea (19%). Of the 35/47 patients followed-up on GFD, only 54% (19/35) showed a complete clinical response. In 9 of 65 patients an intestinal biopsy was also performed after at least ...
Source
#1Siba Prosad Paul (Torbay Hospital)H-Index: 12
#2Bhupinder Kaur Sandhu (University of the West of England)H-Index: 3
Last. P Ramani (Bristol Royal Hospital for Children)H-Index: 7
view all 5 authors...
ABSTRACTObjective:The European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines for diagnosing celiac disease (CD) in children were modified in 2012. They recommend that in symptomatic children with anti-tissue transglutaminase antibody (anti-tTG) titer of >10 tim
Source
#1Johannes WolfH-Index: 13
#2David Petroff (Leipzig University)H-Index: 26
Last. Thomas MothesH-Index: 22
view all 17 authors...
Background & Aims A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, based largely on retrospective data, propose omitting biopsy analysis for patients with concentrations of IgA against tissue transglutaminase (IgA-TTG) >10-fold the upper limit of normal (ULN) and if further criteria are met. A retrospective study concluded that measurements of IgA-TTG and total IgA, or IgA-TTG and IgG against deamidated gl...
Source
#1Salim Hommeida (Mayo Clinic)H-Index: 3
#2Mouaz AlsawasH-Index: 20
Last. Imad AbsahH-Index: 11
view all 6 authors...
The association between celiac disease (CD) and eosinophilic esophagitis (EoE) has been the focus of multiple studies with variable results. Both diseases are immune mediated, and dietary triggers play a role in their pathogenesis. The aim of the study was to analyze the risk of EoE in children with CD, assess the magnitude of association between CD and EoE in children, and report the characteristics and outcomes of children with both conditions. We conducted a retrospective study of the Mayo Cl...
Source
#1Imad Absah (Mayo Clinic)H-Index: 11
#2Abdul Rishi (Mayo Clinic)H-Index: 6
Last. Joseph A. MurrayH-Index: 102
view all 5 authors...
Guidelines for diagnosing celiac disease (CD) recommend initial testing with a highly sensitive serologic test for anti鈥搕issue transglutaminase immunoglobulin A antibodies (tTG IgA). When the probability of CD is high, IgA deficiency should be considered. The 2 approaches to address this include measuring 鈥渂oth tTG IgA and tTG IgG鈥 or measuring 鈥渢otal IgA.鈥 We aim to assess the utility of an isolated positive tTG IgG result in diagnosing CD. We conducted a retrospective review of patients underg...
Source
#1Marleena Repo (UTA: University of Tampere)H-Index: 4
#2Katri Lindfors (UTA: University of Tampere)H-Index: 28
Last. Kalle Kurppa (UTA: University of Tampere)H-Index: 33
view all 9 authors...
Tutkielmaan liittyva artikkeli / Article related to the thesis: Anemia and Iron Deficiency in Children With Potential Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition. 64(1):56鈥62, Jan 2017. DOI: 10.1097/MPG.0000000000001234
Source
Cited By184
Newest
#1Patrizia CalellaH-Index: 8
#2Giuliana ValerioH-Index: 32
Source
#1Arzu EnsariH-Index: 27
Last. Saba KiremitciH-Index: 8
view all 4 authors...
Source
#1Shiva Dahal-KoiralaH-Index: 10
Last. Ludvig M. SollidH-Index: 89
view all 3 authors...
Source
#1Geoffrey Holmes (Royal Derby Hospital)H-Index: 20
Abstract null null Celiac disease is common so that many disorders will occur in association. Diabetes mellitus was the earliest disorder to be described in a child with celiac disease in 1925 (Poynton FJ, Cole LB. A case of celiac disease with glycosuria. Br J Child Dis. 1925;22:30鈥6) and in an adult in 1956 (Finlay JM, Wightman KJR. Modern treatment of the malabsorption syndrome in adults. Ann Intern Med. 1956;45:191鈥206). Since then the number of recognized comorbidities has mushroomed. Inter...
Source
#1Kalle KurppaH-Index: 33
#2Daniel AgardhH-Index: 26
Source
#1Carolina CiacciH-Index: 59
#2Fabiana ZingoneH-Index: 23
Source
#1Alina Popp (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 14
#2Juha TaavelaH-Index: 11
Last. Jorma IsolaH-Index: 100
view all 9 authors...
The original version of the article unfortunately contained an error in the first name and the surname of the all authors in the author group. Below is the corrected first name and the surname of the authors.
Source
#1Ensieh Khalkhal (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 3
#2Mostafa Rezaei-Tavirani (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 20
Last. Haidari Mh (Shahid Beheshti University of Medical Sciences and Health Services)
view all 8 authors...
Background. Celiac disease (CeD) is an autoimmune intestinal disorder caused by gluten protein consumption in genetically predisposed individuals. As biopsy sampling is an invasive procedure, finding novel noninvasive serological markers for screening of at-risk CeD population is a priority. Metabolomics is helpful in monitoring metabolite changes in body fluids and tissues. In the present study, we evaluated serum metabolite levels of CeD patients relative to healthy controls with the aim of in...
Source
#1Giuseppe LosurdoH-Index: 22
#2Milena Di LeoH-Index: 18
Last. Alfredo Di LeoH-Index: 34
view all 8 authors...
Source
The differential diagnosis and treatment of seronegative enteropathy, also termed seronegative villous atrophy (SNVA), is a clinical challenge. Although seronegative coeliac disease (CD) is a frequent cause of SNVA, the aetiology can include immune-mediated, inflammatory, infectious, and drug-related forms. As a misdiagnosis of SNVA can result in patients being unnecessarily placed on a lifelong strict gluten-free diet or even given incorrect immunosuppressive therapy, the aim of this paper is t...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.