Sociology

Organic chemistry

Combinatorial chemistry

Stereochemistry

Catalysis

Chemistry

Anthropology

1,3-Dipolar cycloaddition

Pyrrolidine

Cycloaddition

Diversity (politics)

Azomethine ylide

Chemical Communications

The pyrrolidine ring is a privileged structural motif in synthetic and medicinal chemisty. This review aims to highlight the high versatility of the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides for access to different types of stereochemical patterns in enantioselective pyrrolidine synthesis. Special attention will be paid to stereodivergent procedures giving rise to different stereoisomers from the same starting materials.

Stereochemical diversity in pyrrolidine synthesis by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides