antimicrobial susceptibility

klebsiella pneumoniae

antimicrobial resistance

extended-spectrum lactamase

susceptibility testing

coli isolates

antibiotics

bla ctx-m

antibiotic susceptibility

Infection and Drug Resistance

Global prevalence of antibiotic resistance in blood-isolated Enterococcus faecalis and Enterococcus faecium: a systematic review and meta-analysis Seyedeh Marzieh Jabbari Shiadeh,1 Ali Pormohammad,2 Ali Hashemi,1 Parnian Lak31Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Student Research Committee, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USACorrespondence: Ali PormohammadClinical Microbiology, Shahid Beheshti University of Medical Sciences, Koodakyar Street, Tabnak Blv, Yaman Avenue, Chamran Highway, Tehran, IranTel +98 212 387 2556Fax +98 212 243 9964Email pormohammadali@yahoo.comIntroduction: One of the global concerns is the increasing trend toward antimicrobial resistance and the consequent lack of efficient antimicrobials. Nosocomial infections present a big threat for patients all over the world and treatment with broad-spectrum antibiotics leads to outgrowth of hospital-associated resistant Enterococci clones that are very important in bloodstream infections. We surveyed the frequency and time trend of antibiotic resistance in Enterococci blood isolates from hospitalized patients in different regions of the world.Methods: Literature from January 1, 2000 to May 20, 2018 was searched systematically using Medline (via PubMed), Embase, and Cochrane Library and all original publications on the antibiotic resistance prevalence in blood-isolated Enterococci strains with standard laboratory tests were included. Quality of the included studies was assessed with the modified Critical Appraisal Checklist recommended by the Joanna Briggs Institute. Depending on the heterogeneity test, we used either random or fixed effect models to assess the appropriateness of the pooled prevalence of drug resistance.Results: A total of 291 studies were enrolled in the meta-analysis. Between all antibiot...

Global prevalence of antibiotic resistance in blood-isolated Enterococcus faecalis and Enterococcus faecium: a systematic review and meta-analysis