Gene

Elastic net regularization

Biology

Statistics

Accounting

Biochemistry

Computer science

DNA methylation

Business

Regression analysis

Epigenome

Regression

Variance (accounting)

Mathematics

Econometrics

Mean squared error

Gene expression

Clinical Epigenetics

Elastic net type regression methods have become very popular for prediction of certain outcomes in epigenome-wide association studies (EWAS). The methods considered accept biased coefficient estimates in return for lower variance thus obtaining improved prediction accuracy. We provide guidelines on how to obtain parsimonious models with low mean squared error and include easy to follow walk-through examples for each step in R.

Statistical predictions with glmnet