Internal medicine

Pediatrics

Virus

Hand-foot-and-mouth disease

Disease

Disease control

Infection control

Intensive care medicine

Virology

Vaccination

Immunology

Foot-and-mouth disease

Medicine

The Lancet Child & Adolescent Health

EV-A71 vaccination was effective in preventing non-severe hand, foot, and mouth disease associated with EV-A71 virus infection in children aged 6–71 months, and we found evidence that one dose of vaccination provided partial protection for children aged 24–71 months. Introduction of multivalent vaccines could further reduce the burden of hand, foot, and mouth disease.

Effectiveness of EV-A71 vaccination in prevention of paediatric hand, foot, and mouth disease associated with EV-A71 virus infection requiring hospitalisation in Henan, China, 2017–18: a test-negative case-control study