Internal medicine

Bone marrow failure

Myelodysplastic syndromes

Pathogenesis

Aplastic anemia

Biology

Haematopoiesis

Immunology

Anemia

Stem cell

Myeloid leukemia

Myeloid

Bone marrow

Myelofibrosis

Cytopenia

Cancer research

Genetics

Medicine

Hematology

Aplastic anemia (AA) is a rare and life-threatening bone marrow failure (BMF) that results in peripheral blood cytopenia and reduced bone marrow hematopoietic cell proliferation. The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA complicated. The pathogenesis of AA is complex and its mechanism needs to be deciphered on an individualized basis. This review summarizes several contributions made in trying to understand AA pathogenesis in recent years which may be helpful for the development of personalized therapies for AA.

Pathogenesis of aplastic anemia