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Original paper

Design and analysis of a clinical trial using previous trials as historical control

Volume: 16, Issue: 5, Pages: 531 - 538
Published: Jul 1, 2019
Abstract
Background/Aims For single arm trials, a treatment is evaluated by comparing an outcome estimate to historically reported outcome estimates. Such a historically controlled trial is often analyzed as if the estimates from previous trials were known without variation and there is no trial-to-trial variation in their estimands. We develop a test of treatment efficacy and sample size calculation for historically controlled trials that considers...
Paper Details
Title
Design and analysis of a clinical trial using previous trials as historical control
Published Date
Jul 1, 2019
Volume
16
Issue
5
Pages
531 - 538
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