compounds

culture broth

absolute configurations

cytotoxic activity

endophytic fungus

marine sponge

compounds isolated

Natural Product Communications

A new chlorinated polyketide setosphaerine A (1), together with 3 known ones penicipyran D (2), 7- O-demethymonocerin (3), and monocerin (4), was isolated from the entomogenous fungus Setosphaeria rostrata. The structure of compound 1 was established on the basis of 1D/2D Nuclear Magnetic Resonance (NMR) spectroscopic and High Resolution Electro Spray Ionization Mass Spectra (HR-ESI-MS) data. Compounds 1 to 4 showed moderate cytotoxicity against 3 human tumor cell lines MCF-7, MGC-803, and Hela with IC 50 values ranging from 33 to 243 nM.

Setosphaerine A: A New Chlorinated Polyketide Isolated From the Entomogenous Fungus Setosphaeria rostrata