Hildebrand solubility parameter

Process (computing)

Engineering

Chromatography

Solubility

Operating system

Selection (genetic algorithm)

Solvent extraction

Solvent

Computer science

Biochemical engineering

Extraction (chemistry)

Organic chemistry

Renewable energy

Process engineering

Chemistry

Machine learning

Electrical engineering

TrAC Trends in Analytical Chemistry

Nowadays, green extraction processes are focused on the development of new strategies to achieve sustainable separation processes, promoting the use of alternative solvents from renewable sources. Green solvents have risen as an option that can replace petroleum based solvents, however, they should retain the same extraction properties and technological features. The choice of the solvent is a crucial step in the solvent-substitution process, so Hansen solubility parameters (HSP) have been successfully used as a real decision-making tool. For the first time, this work aims to give an overview of HSP as solvent selection tool for extraction of bioactive compounds from natural products. It includes a brief description about the emerging green solvents extraction, the HSP theory and an updated discussion of the most recent publications (from 2009 till January 2019). Finally, some concluding remarks about the importance of using this solvent selection approach in the near future are included.

Hansen solubility parameters for selection of green extraction solvents