Adhesive

Adhesion

Engineering

Bioadhesive

Biotechnology

Biology

Biomedical engineering

Metallurgy

Materials science

Surgery

Layer (electronics)

Biochemistry

Secretion

Immunology

Drug delivery

In vivo

Nanotechnology

Organic chemistry

Ex vivo

In vitro

Biocompatibility

Composite material

Medicine

Chemistry

Wound healing

Advanced Functional Materials

Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD‐based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD‐based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD‐based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

A Bioinspired Medical Adhesive Derived from Skin Secretion of <i>Andrias davidianus</i> for Wound Healing

A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing