Radiology

Pathology

Neuroscience

Disease

Dementia

Stroke (engine)

Ischemia

Pathophysiology

Epistemology

Magnetic resonance imaging

Engineering

Cardiology

Philosophy

Intensive care medicine

Psychology

Lacunar stroke

CADASIL

Autopsy

Mechanism (biology)

Ischemic stroke

Neuroimaging

Medicine

Mechanical engineering

Journal of Stroke and Cerebrovascular Diseases

Since the term “lacune” was adopted in the 1800s to describe infarctions from cerebral small vessels, their underlying pathophysiological basis remained obscure until the 1960s when Charles Miller Fisher performed several autopsy studies of stroke patients. He observed that the vessels displayed segmental arteriolar disorganization that was associated with vessel enlargement, hemorrhage, and fibrinoid deposition. He coined the term “lipohyalinosis” to describe the microvascular mechanism that engenders small subcortical infarcts in the absence of a compelling embolic source.

Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations