Clinical Practice

Engineering

Biology

Cholesterol

Statement (logic)

Cardiology

Atherosclerotic cardiovascular disease

Environmental health

Lipoprotein(a)

Biomarker

Mechanical engineering

Genetics

Stroke (engine)

Political science

Lipoprotein

Physical therapy

Population

Myocardial infarction

Internal medicine

Medicine

Observational study

Disease

Journal of clinical lipidology

Lipoprotein(a) [Lp(a)] is a well-recognized, independent risk factor for atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in 20% of the population. Observational and genetic evidence strongly support a causal relationship between high plasma concentrations of Lp(a) and increased risk of atherosclerotic cardiovascular disease-related events, such as myocardial infarction and stroke, and valvular aortic stenosis. In this scientific statement, we review an array of evidence-based considerations for testing of Lp(a) in clinical practice and the utilization of Lp(a) levels to inform treatment strategies in primary and secondary prevention.

Use of Lipoprotein(a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association