Physics

Organic chemistry

Combinatorial chemistry

Phosphine

Chiral symmetry breaking

Stereochemistry

Enantioselective synthesis

Chirality (physics)

Catalysis

Axial chirality

Symmetry breaking

Nambu–Jona-Lasinio model

Atropisomer

Stereoselectivity

Chemistry

Cycloaddition

Pyrrole

Alkyl

Quantum mechanics

Aryl

Organocatalysis

ACS Catalysis

Developing an efficient and reliable catalytic protocol to access atropisomeric compounds, especially those bearing five-membered heteroaryl structures with lower rotation barriers, is a challenging task. Here, we disclose an unprecedented atropenantioselective Barton–Zard reaction via a central-to-axial chirality transfer strategy, by employing α-substituted nitroolefins with a β-ortho-substituted (hetero)aryl group and α-isocyano substrates with various electron-withdrawing groups, under the catalysis of Ag2O and a cinchona-derived phosphine ligand, providing a robust approach to construct axially chiral 3-(hetero)aryl pyrroles with a substantial skeleton and functionality versatility. An alternative asymmetric phase transfer catalysis protocol was also demonstrated to be practical for the direct construction of axially chiral bisphosphine dioxides. In addition, good conformational stability is generally observed for the obtained atropisomers, and their potential application as valuable organocatalysts has been well demonstrated in a highly stereoselective formal [4 + 2] cycloaddition reaction.

Asymmetric Barton–Zard Reaction To Access 3-Pyrrole-Containing Axially Chiral Skeletons