Messenger RNA

Duration (music)

Physics

Translation (biology)

In vivo

Immunogenicity

Biology

Gene

Virology

Acoustics

Computational biology

Cell biology

Genetics

Immune system

Molecular Cell

Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo