Catalysis

Organic synthesis

Electrophile

Alkene

Medicinal chemistry

Combinatorial chemistry

Organic chemistry

Nucleophile

Propargyl

Carbocation

Chemistry

Iodobenzene

Advanced Synthesis & Catalysis

2‐Propargyl alcohols are widely used in organic reactions. Their great success is rooted in the presence of multiple functional groups. This review will focus on six types of mechanisms: (i) 2‐propargyl alcohols as carbocation precursors, (ii) alkynes as electrophiles, (iii) alcohols as nucleophiles, (iv) fracture via ketones or elimination into alkene intermediates, (v) oxidation into alkynyl‐ ortho ‐quinone methides or carbonyl intermediates, and (vi) ring expansions. Reactions involving alkanes, alkenes, alkynes, arenes, alcohols, amines, amides, ketones, CO 2 , hydrazine, iodobenzene, azides, carbenes, arylboronic acids, etc. will be discussed. We hope that this review will help to promote future research in this area. magnified image

2‐Propargyl Alcohols in Organic Synthesis