Gene

Glycoconjugate

Engineering

Posttranslational modification

Biology

Messenger RNA

Materials science

Oligosaccharide

Glycoprotein

Biochemistry

Computational biology

Translation (biology)

Glycosylation

Biochemical engineering

Combinatorial chemistry

Nanotechnology

Glycan

Enzyme

Chemistry

Biomolecule

Journal of the American Chemical Society

The translation of biological glycosylation in humans to the clinical applications involves systematic studies using homogeneous samples of oligosaccharides and glycoconjugates, which could be accessed by chemical, enzymatic or other biological methods. However, the structural complexity and wide-range variations of glycans and their conjugates represent a major challenge in the synthesis of this class of biomolecules. To help navigate within many methods of oligosaccharide synthesis, this Perspective offers a critical assessment of the most promising synthetic strategies with an eye on the therapeutically relevant targets.

Oligosaccharide Synthesis and Translational Innovation