Review paper
Antibody–drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes
Abstract
Targeted delivery of therapeutic molecules into cancer cells is considered as a promising strategy to tackle cancer. Antibody-drug conjugates (ADCs), in which a monoclonal antibody (mAb) is conjugated to biologically active drugs through chemical linkers, have emerged as a promising class of anticancer treatment agents, being one of the fastest growing fields in cancer therapy. The failure of early ADCs led researchers to explore strategies to...
Paper Details
Title
Antibody–drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes
Published Date
Nov 27, 2018
Volume
234
Issue
5
Pages
5628 - 5642
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