Internal medicine

Triple negative

Methylation

Biology

Gene

Cancer

Oncology

microRNA

HMGA2

Chemotherapy

Triple-negative breast cancer

Breast cancer

EZH2

Cancer research

Biochemistry

Medicine

Cancer Research

Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 proteins is observed in

The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer