Internal medicine

Obesity

Bioinformatics

Biology

Endocrinology

Adipokine

Insulin resistance

Dyslipidemia

Cholesterol

Lipoprotein

PCSK9

LDL receptor

Medicine

Metabolism

Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines. However, recent evidence suggests that obesity-induced dyslipidemia is not a unique pathophysiological entity, but rather has distinct characteristics depending on many individual factors. In line with that, in a subgroup of metabolically healthy obese (MHO) individuals, dyslipidemia is less prominent or even absent. In this review, we will address the main characteristics of dyslipidemia and mechanisms that induce its development in obesity.

Obesity and dyslipidemia