Leaky gut biomarkers in depression and suicidal behavior

Objective Inflammation is associated with major depressive disorder ( MDD ) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt ( rSA ), MDD subjects with no history of a suicide attempt (ns MDD ), and healthy controls (...