Synergistic effects of citric acid - sodium alginate on physicochemical properties of α-tricalcium phosphate bone cement

Calcium phosphate bone cement is one of the most widely used bone substitutes, but its clinical use is still critically limited by its poor physicochemical properties. In this work, calcium-binding agents, citric acid (CA) and sodium alginate (SA), were jointly introduced into α-tricalcium phosphate (α-TCP) cement to improve its physicochemical properties. Effects of CA and SA on the phase, morphology, deformation, handling and mechanical...