Histone

Gene

Function (biology)

Cell biology

Neuroscience

Biology

Nicotinamide adenine dinucleotide

SIRT2

Neurodegeneration

Biochemistry

Downregulation and upregulation

SIRT3

NAD+ kinase

Sirtuin

Acetylation

SIRT6

Enzyme

Internal medicine

Nicotinamide

Sirtuin 1

Medicine

Chemistry

Disease

Gene isoform

European Journal of Medicinal Chemistry

Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies.

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators