Intensive care medicine

Surgery

Hyperinsulinism

Endocrinology

Hypoglycemia

Insulin

Hyperinsulinemia

Pediatrics

Congenital hyperinsulinism

Insulin resistance

Internal medicine

Medicine

Diazoxide

Disease

Diabetes mellitus

Diabetic Medicine

Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and dysregulated insulin secretion (hyperinsulinism) from disordered pancreatic β cells can often lead to irreversible brain damage with lifelong neurodisability. Although congenital hyperinsulinism has a genetic cause in a significant proportion (40%) of children, often being the result of mutations in the genes encoding the K

Therapies and outcomes of congenital hyperinsulinism‐induced hypoglycaemia