Gerontology

Neuroscience

Biology

Muscle mass

Skeletal muscle

Environmental health

Sarcopenia

Physiology

Life style

Ageing

Anatomy

Internal medicine

Medicine

Wasting

Biogerontology

As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with changes in numerous important mechanisms all contributing to the structural and functional deterioration. Here, we review the major proposed changes which occur in skeletal muscle during ageing and highlight evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting.

Age-related changes in skeletal muscle: changes to life-style as a therapy