Gene

microRNA

Cell biology

Biotechnology

Biology

Mesenchymal stem cell

Biomedical engineering

Materials science

Microvesicles

Surgery

Transplantation

Stem cell

Tissue engineering

Regeneration (biology)

Biochemistry

Humanities

In vivo

Nanotechnology

Curcumin

Nanoparticle tracking analysis

Stem-cell therapy

Pharmacology

Curitiba

Medicine

Chemistry

Cell

Adipose tissue

Pathology

International Journal of Nanomedicine

Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems.In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done.Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking.This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies.

Fluorescence properties of curcumin-loaded nanoparticles for cell tracking