Catalysis

Nucleophilic addition

Enantioselective synthesis

Engineering

Organic synthesis

Materials science

Biochemical engineering

Combinatorial chemistry

Nanotechnology

Organic chemistry

Nucleophile

Chemistry

Tertiary alcohols

Advanced Synthesis & Catalysis

Chiral tertiary alcohols are an important class of organic compounds which have found wide applications in both academia and industry. Therefore, various synthetic strategies towards these compounds have already been developed. Among them, the catalytic asymmetric addition of carbon nucleophiles to ketones is the most desirable route owing to its straightforwardness as well as its economic, efficient and versatile advantages. This review summarizes and discusses the recent achievements in this field classified according to the reaction types. Special attention is paid to the mechanisms, advantages and limitations of each reaction. In addition, the applications of these catalytic processes in the synthesis of related natural products, pharmaceuticals or their analogues are briefly discussed as well.

Recent Advances in Catalytic Asymmetric Synthesis of Tertiary Alcohols <i>via</i> Nucleophilic Addition to Ketones

Recent Advances in Catalytic Asymmetric Synthesis of Tertiary Alcohols via Nucleophilic Addition to Ketones