Physics

Radiology

Biology

Speckle pattern

Optics

Microcirculation

Biomedical engineering

Paleontology

Materials science

Optical tomography

Optical coherence tomography

Biological tissue

Context (archaeology)

Computer science

Optoelectronics

Medicine

Optical imaging

Journal of Biomedical Optics

Nowadays, dynamically developing optical (photonic) technologies play an ever-increasing role in medicine. Their adequate and effective implementation in diagnostics, surgery, and therapy needs reliable data on optical properties of human tissues, including skin. This paper presents an overview of recent results on the measurements and control of tissue optical properties. The issues reported comprise a brief review of optical properties of biological tissues and efficacy of optical clearing (OC) method in application to monitoring of diabetic complications and visualization of blood vessels and microcirculation using a number of optical imaging technologies, including spectroscopic, optical coherence tomography, and polarization- and speckle-based ones. Molecular modeling of immersion OC of skin and specific technique of OC of adipose tissue by its heating and photodynamic treatment are also discussed.

Measurement of tissue optical properties in the context of tissue optical clearing