Displacement of the transcription factor B reader domain during transcription initiation
Abstract
Transcription initiation by archaeal RNA polymerase (RNAP) and eukaryotic RNAP II requires the general transcription factor (TF) B/ IIB. Structural analyses of eukaryotic transcription initiation complexes locate the B-reader domain of TFIIB in close proximity to the active site of RNAP II. Here, we present the first crosslinking mapping data that describe the dynamic transitions of an archaeal TFB to provide evidence for structural...
Paper Details
Title
Displacement of the transcription factor B reader domain during transcription initiation
Published Date
Aug 8, 2018
Journal
Volume
46
Issue
19
Pages
10066 - 10081
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