Internal medicine

Enzyme

Mitochondrial permeability transition pore

Apoptosis

Chemistry

Lactate dehydrogenase

Programmed cell death

Creatine kinase

Biochemistry

Medicine

Pharmacology

Basic Research in Cardiology

Adenosine diphosphate ANOVA Analysis of variance ATP Adenosine triphosphate CK Creatine kinase CK-MB Creatine kinase-muscle/brain CMR Cardiac magnetic resonance imaging CsA Cyclosporine A ECG Electrocardiogram EGTA Ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid FCCP Carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone FCS Fetal calf serum HEPES 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ICH International conference on harmonization IFM Interfibrillar mitochondria JC-1 Tetraethyl-benzimidazolyl-carbocyanine iodide KHB Krebs-Henseleit buffer LDH Lactate dehydrogenase LGE Late gadolinium enhancement LOCF Last observation carried forward MACCE Major adverse cardiac and cerebral events MOPS 3-(N-morpholino)propanesulfonic acid mPTP Mitochondrial permeability transition pore MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium PPCI Primary percutaneous coronary intervention RNA Ribonucleic acid ROS Reactive oxygen species SPECT Single-photon emission computed tomography SSM Subsarcolemmal mitochondria STEMI ST segment elevation myocardial infarction T2w-CMR T2-weighted cardiac magnetic resonance imaging TMRE Ethyl ester of tetramethylrhodamine TMRM Methyl ester of tetramethylrhodamine TTC 2,3,5-triphenyl tetrazolium chloride

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection