Control of Inflammasome Activation by Phosphorylation

Phosphorylation modification regulates inflammasome activation by targeting different inflammasome components, including NLRP3, Pyrin, NLRC4, IFI16, ASC, and caspase-1. Phosphorylation regulates the priming, self-assembly, localization, and degradation of NLRP3 inflammasome through numerous phosphorylation events. Inactivation of Rho GTPase by bacterial toxins results in dephosphorylation of Pyrin, dissociation of 14-3-3 proteins, and Pyrin...