Intensive care medicine

Metallurgy

Materials science

Nephrology

Biochemistry

Hemodialysis

Environmental health

Organic chemistry

Membrane

End stage renal disease

Oxidative stress

Population

Internal medicine

Biocompatibility

Medicine

Chemistry

Disease

Dialysis

Journal of Artificial Organs

End-stage renal disease is a growing health problem with increasing prevalence and high health care costs. Patients suffering from end-stage renal disease exhibit higher morbidity and mortality rates compared to the general population. These patients, who are treated using hemodialysis, typically suffer from anemia, inflammation, and oxidative stress. Inadequate dialyzer membrane biocompatibility exacerbates these negative side effects. Modifications of the composition of hemodialysis membranes have improved their biocompatibility and improve the patients’ quality of life. Recently, the use of dialyzer membranes coated with bioactive compounds has also been proposed to further ameliorate dialysis-associated problems. Based on a survey of the current literature, application of bioactive membranes decreases the inflammation and oxidative stress of patients treated with hemodialysis.

The biocompatibility and bioactivity of hemodialysis membranes: their impact in end-stage renal disease