Organic chemistry

Polymer chemistry

Combinatorial chemistry

Mathematics

Dehydrogenation

Amine gas treating

Catalysis

Mathematical analysis

Chemistry

Pyrazine

Quinoxaline

Metal

Base (topology)

Manganese

Pincer movement

ACS Catalysis

Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcohols to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.

Synthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes