Cytoskeleton

Cell

Microtubule

Biology

Cancer

Vinca

Paclitaxel

Microtubule-associated protein

Tubulin

Cell biology

Genetics

Biochemistry

Intracellular

Pharmacology

Trends in Cell Biology

Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among the most important medical weapons available to combat cancer. MTAs interfere with intracellular transport, inhibit eukaryotic cell proliferation, and promote cell death by suppressing microtubule dynamics. Recent advances in the structural analysis of MTAs have enabled the extensive characterization of their interactions with microtubules and their building block tubulin. We review here our current knowledge on the molecular mechanisms used by MTAs to hijack the microtubule cytoskeleton, and discuss dual inhibitors that target both kinases and microtubules.

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton