Birch reduction

Ammonia

Dentistry

Combinatorial chemistry

Organic chemistry

Mathematics

Crown (dentistry)

Geometry

Medicine

Chemistry

Crown ether

Ether

Reduction (mathematics)

Organic Letters

A novel protocol for a significantly improved, practical, and chemoselective ammonia-free Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 ether is reported. A broad range of aromatic and heteroaromatic compounds is reduced with excellent yields.

A Practical and Chemoselective Ammonia-Free Birch Reduction