Internal medicine

Cell

Insulitis

Autoimmunity

Diabetes mellitus

Biology

Gene

Recombination-activating gene

Endocrinology

Recombination

Islet

Apoptosis

Immunology

T cell

NOD mice

Pancreatic islets

Programmed cell death

Type 1 diabetes

Biochemistry

Medicine

Immune system

Scientific Reports

Type 1 diabetes is caused by autoreactive T cell-mediated β cell destruction. Even though co-inhibitory receptor programmed death-1 (PD-1) restrains autoimmunity, the expression and regulation of its cognate ligands on β cell remains unknown. Here, we interrogated β cell-intrinsic programmed death ligand-1 (PD-L1) expression in mouse and human islets. We measured a significant increase in the level of PD-L1 surface expression and the frequency of PD-L1

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes