Internal medicine

Pathology

Enzyme

Disease

Duodenal bulb

Atrophy

Villous atrophy

Biology

Gastroenterology

Antibody

Tissue transglutaminase

Immunology

Biopsy

Duodenum

Coeliac disease

Immunoglobulin A

Gluten free

Intestinal mucosa

Immunoglobulin G

Biochemistry

Medicine

Gastrointestinal Endoscopy

Anti-tissue transglutaminase antibodies (anti-tTG) have simplified celiac disease (CD) diagnosis. However, in atypical forms of CD, intestinal biopsy sampling is still required. This prospective study investigates whether histologic analysis of the duodenal bulb combined with intestinal IgA anti-tTG deposit immunoassay makes CD diagnosis possible in at-risk children with low concentrations of serum anti-tTG.

Immunohistologic analysis of the duodenal bulb: a new method for celiac disease diagnosis in children