Ligand (biochemistry)

Receptor

Organic chemistry

Combinatorial chemistry

Ring (chemistry)

Stereochemistry

Amine gas treating

Enantioselective synthesis

Catalysis

Chemistry

Ethylenediamine

Biochemistry

Journal of the American Chemical Society

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)–H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

Pd(II)-Catalyzed Enantioselective C(sp<sup>3</sup>)–H Arylation of Free Carboxylic Acids

Pd(II)-Catalyzed Enantioselective C(sp3)–H Arylation of Free Carboxylic Acids

Pd(II)-Catalyzed Enantioselective C(sp³)–H Arylation of Free Carboxylic Acids