Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility
Abstract
Genetic drugs based on RNA or DNA have remarkable therapeutic potential as virtually any disease can be treated by silencing a pathological gene, expressing a beneficial protein, or by editing defective genes. However, therapies based on nucleic acid polymers require sophisticated delivery systems to deliver these macromolecules to the interior of target cells. In this study, we review progress in developing nonviral lipid nanoparticle (LNP)...
Paper Details
Title
Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility
Published Date
Jun 1, 2018
Journal
Volume
28
Issue
3
Pages
146 - 157
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History