Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update
Abstract
Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing a unique yet essential selenocysteine residue at their C-terminus. TrxRs, together with their endogenous substrate thioredoxins, play a crucial role in regulating diverse cellular redox events. A wealth of evidence from both clinic observations and bench studies supports that overactivation/dysfunction of TrxRs has a close link to the onset and development of...
Paper Details
Title
Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update
Published Date
May 4, 2018
Journal
Volume
39
Issue
1
Pages
5 - 39
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