Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives
Abstract
Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer chemotherapy. This valuable class of alkylating agent exerts its biological activity by binding to DNA, cross linking two strands, preventing DNA replication and ultimate cell death. At the molecular level, nitrogen lone pairs of nitrogen mustard generate a strained intermediate...
Paper Details
Title
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives
Published Date
May 1, 2018
Volume
151
Pages
401 - 433
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Notes
History