Spectroscopy

Quantum mechanics

Dapagliflozin

Type 2 diabetes

Chromatography

Endocrinology

Computer science

Insulin

Physics

Sitagliptin

Internal medicine

Medicine

Chemistry

Saxagliptin

Metformin

Diabetes mellitus

Pharmaceutica Analytica Acta

A new approach developed for stability-indicating, simultaneous estimation of Saxagliptin and Dapagliflozin in rat serum by using UV spectroscopy.Saxagliptin detection wave length was at 222 nm with water is solvent and Dapagliflozin detection wave length was at 274 nm with phosphate buffer pH 6.8 is solvent.Both drugs are obeyed the beers-lamberts concentration range was founds to be 1-10 µg/mL.The present method was optimized and validated in spiked rat serum according to ICH guidelines.All validation parameters were found to be within the acceptable limits and stability-indicating studies were conducted under different conditions founds in negligible.The present method was simple and sensitive; it was successfully adopted for the simultaneous estimation of Saxagliptin and Dapagliflozin in rat serum samples by using UV spectroscopy.

A Novel Stability-Indicating Method for the Simultaneous Estimation of Saxagliptin and Dapagliflozin in Rat Serum by Using UV Spectroscopy